Contents Hypersensitivity to the drug. Possible side effects in the instructions are not described. Isotretinoin – a drug with antiseborrheic action. Indications for use The drug is prescribed for the treatment of severe forms of acne (acne), which is not amenable to therapy by other means. Contraindications Hepatic and renal failure; Simultaneous use with methotrexate; Pregnancy, childbearing age in women; …